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A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway

Clustered protocadherins (Pcdhs) are arranged in gene clusters (α, β, and γ) with variable and constant exons. Variable exons encode cadherin and transmembrane domains and ∼90 cytoplasmic residues. The 14 Pcdh-αs and 22 Pcdh-γs are spliced to constant exons, which, for Pcdh-γs, encode ∼120 residues...

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Main Authors: O'Leary, Robert, Reilly, James E., Hanson, Hugo H., Kang, Semie, Lou, Nicole, Phillips, Greg R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216661/
https://ncbi.nlm.nih.gov/pubmed/21917590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-04-0283
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