Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress

We previously demonstrated that CBF activity is needed for cell proliferation and early embryonic development. To examine the in vivo function of CBF in differentiated hepatocytes, we conditionally deleted CBF-B in hepatocytes after birth. Deletion of CBF-B resulted in progressive liver injury and s...

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Bibliografiska uppgifter
Huvudupphovsmän: Luo, Rong, Klumpp, Sherry A., Finegold, Milton J., Maity, Sankar N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216617/
https://ncbi.nlm.nih.gov/pubmed/22355653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00136
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