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Mechanism of copper(II)-induced misfolding of Parkinson's disease protein
α-synuclein (aS) is a natively unfolded pre-synaptic protein found in all Parkinson's disease patients as the major component of fibrillar plaques. Metal ions, and especially Cu(II), have been demonstrated to accelerate aggregation of aS into fibrillar plaques, the precursors to Lewy bodies. In...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3216499/ https://ncbi.nlm.nih.gov/pubmed/22355530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00011 |
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