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Sensitized Splenocytes Result in Deleterious Cytokine Cascade and Hyperinflammatory Response in Rats with Pneumocystis Pneumonia despite the Presence of Corticosteroids

The immune response to the opportunistic pulmonary pathogen Pneumocystis can have beneficial and harmful effects on the host despite the presence of corticosteroids. We hypothesized that this deleterious hyperinflammatory response is associated with exaggerated cytokine production. The adoptive tran...

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Autors principals: Thullen, Timothy D., Ashbaugh, Alan D., Daly, Kieran R., Linke, Michael J., Steele, Paul E., Walzer, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC321630/
https://ncbi.nlm.nih.gov/pubmed/14742518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.2.757-765.2004
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