Novel Pyridopyrazine and Pyrimidothiazine Derivatives as FtsZ Inhibitors

A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from M. tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activ...

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Bibliographic Details
Main Authors: Mathew, Bini, Srivastava, Shefali, Ross, Larry J., Suling, William J., White, E. Lucile, Woolhiser, Lisa K., Lenaerts, Anne J., Reynolds, Robert C.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216299/
https://ncbi.nlm.nih.gov/pubmed/22024272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.062
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