Generation of Yersinia pestis Attenuated Strains by Signature-Tagged Mutagenesis in Search of Novel Vaccine Candidates

In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the causative agent of plague, a signature-tagged mutagenesis strategy was used and optimized for a subcutaneously infected mouse model. A library of tagged mutants of the virulent Y. pestis Kimberley53 strain was g...

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Detalhes bibliográficos
Main Authors: Flashner, Yehuda, Mamroud, Emanuelle, Tidhar, Avital, Ber, Raphael, Aftalion, Moshe, Gur, David, Lazar, Shirley, Zvi, Anat, Bino, Tamar, Ariel, Naomi, Velan, Baruch, Shafferman, Avigdor, Cohen, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Molecular Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321629/
https://ncbi.nlm.nih.gov/pubmed/14742535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.2.908-915.2004
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