Detection of DNA mismatch repair proteins in fresh human blood lymphocytes - towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening

BACKGROUND: A broad population-based assay to detect individuals with Lynch Syndrome (LS) before they develop cancer would save lives and healthcare dollars via cancer prevention. LS is caused by a germline mutation in a DNA mismatch repair (MMR) gene, especially protein truncation-causing mutations...

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Bibliografiska uppgifter
Huvudupphovsmän: Hassen, Samar, Boman, Bruce M, Ali, Nawab, Parker, Marcie, Somerman, Chandra, Ali-Khan Catts, Zohra J, Ali, Akhtar A, Fields, Jeremy Z
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216249/
https://ncbi.nlm.nih.gov/pubmed/22017758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-30-100
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