Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors

BACKGROUND: Motesanib is a potent inhibitor of VEGFR1, 2 and 3, PDGFR and Kit receptors. In this report we examine the interaction between motesanib and radiation in vitro and in head and neck squamous cell carcinoma (HNSCC) xenograft models. EXPERIMENTAL DESIGN: In vitro assays were performed to as...

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Main Authors: Kruser, Tim J., Wheeler, Deric L., Armstrong, Eric A., Iida, Mari, Kozak, Kevin R., van der Kogel, Albert J., Bussink, Johan, Coxon, Angela, Polverino, Anthony, Harari, Paul M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216115/
https://ncbi.nlm.nih.gov/pubmed/20507929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3385
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