Two Studies Evaluating the Safety and Immunogenicity of a Live, Attenuated Shigella flexneri 2a Vaccine (SC602) and Excretion of Vaccine Organisms in North American Volunteers

We report the first community-based evaluation of Shigella flexneri 2a strain SC602, a live, oral vaccine strain attenuated by deletion of the icsA (virG) plasmid virulence gene, given at 10(4) CFU. The primary objectives of this trial were to determine the safety and immunogenicity of the vaccine a...

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Autori principali: Katz, David E., Coster, Trinka S., Wolf, Marcia K., Trespalacios, Fernando C., Cohen, Dani, Robins, Guy, Hartman, Antoinette B., Venkatesan, Malabi M., Taylor, David N., Hale, Thomas L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC321603/
https://ncbi.nlm.nih.gov/pubmed/14742537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.2.923-930.2004
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