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Partial Restoration of the Long QT Syndrome Associated KCNQ1 A341V Mutant by the KCNE1 β-Subunit
BACKGROUND: The A341V mutation in the pore-forming KCNQ1 subunit of the slowly activating delayed-rectifier potassium current (IKs) underlies a common form of the long QT syndrome, and is associated with an unusually severe phenotype. However, there is controversy regarding the underlying mechanism...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3215802/ https://ncbi.nlm.nih.gov/pubmed/21854832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2011.07.018 |
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