Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform

Nucleic acid-based aptamers offer many potential advantages relative to antibodies and other protein-based affinity reagents, including facile chemical synthesis, reversible folding, improved thermal stability and lower cost. However, their selection requires significant time and resources and selec...

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Main Authors: Ahmad, Kareem M., Oh, Seung Soo, Kim, Seon, McClellen, Forrest M., Xiao, Yi, Soh, H. Tom
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215713/
https://ncbi.nlm.nih.gov/pubmed/22110600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027051
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