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Contribution of CsrR-Regulated Virulence Factors to the Progress and Outcome of Murine Skin Infections by Streptococcus pyogenes

Streptococcus pyogenes with null mutations in the csrRS regulatory locus are highly virulent in mice due to derepression of hyaluronic acid capsule synthesis and exotoxins, e.g., streptolysin S (SLS) and pyrogenic exotoxin B (SpeB). We generated derivatives of a ΔcsrRS strain that also carry deletio...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Engleberg, N. Cary, Heath, Andrew, Vardaman, Kristal, DiRita, Victor J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321567/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14742501/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.2.623-628.2004
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