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Nucleostemin inhibits TRF1 dimerization and shortens its dynamic association with the telomere

TRF1 is a key component of the telomere-capping complex and binds double-strand telomeric DNA as homodimers. So far, it is not clear whether TRF1 dimerization coincides with its telomere binding or is actively controlled before it binds the telomere, and in the latter case, how this event might affe...

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Detalhes bibliográficos
Main Authors: Meng, Lingjun, Hsu, Joseph K., Zhu, Qubo, Lin, Tao, Tsai, Robert Y. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215579/
https://ncbi.nlm.nih.gov/pubmed/22045740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.089672
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