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Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

BMS-433771 was found to be a potent inhibitor of respiratory syncytial virus (RSV) replication in vitro. It exhibited excellent potency against multiple laboratory and clinical isolates of both group A and B viruses, with an average 50% effective concentration of 20 nM. Mechanism-of-action studies d...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Cianci, Christopher, Yu, Kuo-Long, Combrink, Keith, Sin, Ny, Pearce, Bradley, Wang, Alan, Civiello, Rita, Voss, Stacey, Luo, Guangxiang, Kadow, Kathy, Genovesi, Eugene V., Venables, Brian, Gulgeze, Hatice, Trehan, Ashok, James, Jennifer, Lamb, Lucinda, Medina, Ivette, Roach, Julia, Yang, Zheng, Zadjura, Lisa, Colonno, Richard, Clark, Junius, Meanwell, Nicholas, Krystal, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2004
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321540/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14742189/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.2.413-422.2004
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