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Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease
Mammalian cells have evolved sophisticated DNA repair systems to correct mispaired or damaged bases and extrahelical loops. Emerging evidence suggests that, in some cases, the normal DNA repair machinery is “highjacked” to become a causative factor in mutation and disease, rather than act as a safeg...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3215281/ https://ncbi.nlm.nih.gov/pubmed/18472310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.03.013 |
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