The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis

BACKGROUND: The first telomerase-associated protein (Est1) was isolated in yeast due to its essential role in telomere maintenance. The human counterparts EST1A, EST1B, and EST1C perform diverse functions in nonsense-mediated mRNA decay (NMD), telomere length homeostasis, and telomere transcription....

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Bibliographic Details
Main Authors: Sealey, David CF, Kostic, Aleksandar D, LeBel, Catherine, Pryde, Fiona, Harrington, Lea
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215184/
https://ncbi.nlm.nih.gov/pubmed/22011238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-12-45
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