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Theory and simulation of diffusion-influenced, stochastically gated ligand binding to buried sites
We consider the diffusion-influenced rate coefficient of ligand binding to a site located in a deep pocket on a protein; the binding pocket is flexible and can reorganize in response to ligand entrance. We extend to this flexible protein-ligand system a formalism developed previously [A. M. Berezhko...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Institute of Physics
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3215080/ https://ncbi.nlm.nih.gov/pubmed/22010732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3645000 |
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