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Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis

The circadian clock generates daily rhythms in mammalian liver processes, such as glucose and lipid homeostasis, xenobiotic metabolism, and regeneration. The mechanisms governing these rhythms are not well understood, particularly the distinct contributions of the cell-autonomous clock and central p...

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Autors principals: Atwood, Ann, DeConde, Robert, Wang, Susanna S., Mockler, Todd C., Sabir, Jamal S. M., Ideker, Trey, Kay, Steve A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215069/
https://ncbi.nlm.nih.gov/pubmed/22042857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115753108
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