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Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia
Epithelial bending is a central feature of morphogenesis in animals. Here we show that mutual antagonism by the small Rho GTPases Rac1 and RhoA determines cell shape, tissue curvature, and invagination activity in the model epithelium of the developing mouse lens. The epithelial cells of the invagin...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3215052/ https://ncbi.nlm.nih.gov/pubmed/22021442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108993108 |
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