Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expressing four transcription factors: Oct4, Sox2, Klf4, and c-Myc. Here we report that enhancing RA signaling by expressing RA receptors (RARs) or by RA agonists profoundly promoted reprogramming, but inhibiting it using...

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Detalhes bibliográficos
Main Authors: Wang, Wei, Yang, Jian, Liu, Hui, Lu, Dong, Chen, Xiongfeng, Zenonos, Zenon, Campos, Lia S., Rad, Roland, Guo, Ge, Zhang, Shujun, Bradley, Allan, Liu, Pentao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215025/
https://ncbi.nlm.nih.gov/pubmed/21990348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100893108
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