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Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella

Unlike broad-host Salmonella serovars, which cause self-limiting disease, Salmonella enterica serovar Typhi can infect only humans causing typhoid fever, a life-threatening systemic disease. The molecular bases for these differences are presently unknown. Here we show that the GTPase Rab29 (Rab7L1)...

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Bibliographic Details
Main Authors: Spanò, Stefania, Liu, Xiaoyun, Galán, Jorge E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215007/
https://ncbi.nlm.nih.gov/pubmed/22042847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111959108
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