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Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella
Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the replication of intra-vacuolar pathogens such as Salmonella. Here we show that this mechanism requires aconitate decarboxylase 1 (IRG1), which synthesizes itaconate, a metabolite with antimicrobial activity. We find that Rab...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8020367/ https://ncbi.nlm.nih.gov/pubmed/32703879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz1333 |
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