Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a multiorgan genetic disease in which brain involvement causes epilepsy, intellectual disability, and autism. The hallmark pathological finding in TSC is the cerebral cortical tuber and its unique constituent, giant cells. However, an animal model that replicates...

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Detalhes bibliográficos
Main Authors: Goto, June, Talos, Delia M., Klein, Peter, Qin, Wei, Chekaluk, Yvonne I., Anderl, Stefanie, Malinowska, Izabela A., Di Nardo, Alessia, Bronson, Roderick T., Chan, Jennifer A., Vinters, Harry V., Kernie, Steven G., Jensen, Frances E., Sahin, Mustafa, Kwiatkowski, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214999/
https://ncbi.nlm.nih.gov/pubmed/22025691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106454108
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