Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a multiorgan genetic disease in which brain involvement causes epilepsy, intellectual disability, and autism. The hallmark pathological finding in TSC is the cerebral cortical tuber and its unique constituent, giant cells. However, an animal model that replicates...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Goto, June, Talos, Delia M., Klein, Peter, Qin, Wei, Chekaluk, Yvonne I., Anderl, Stefanie, Malinowska, Izabela A., Di Nardo, Alessia, Bronson, Roderick T., Chan, Jennifer A., Vinters, Harry V., Kernie, Steven G., Jensen, Frances E., Sahin, Mustafa, Kwiatkowski, David J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2011
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214999/
https://ncbi.nlm.nih.gov/pubmed/22025691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106454108
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