A Mutant Form of the Neisseria gonorrhoeae Pilus Secretin Protein PilQ Allows Increased Entry of Heme and Antimicrobial Compounds

A spontaneous point mutation in pilQ (pilQ1) resulted in phenotypic suppression of a hemoglobin (Hb) receptor mutant (hpuAB mutant), allowing gonococci to grow on Hb as the sole source of iron. PilQ, formerly designated OMP-MC, is a member of the secretin family of proteins located in the outer memb...

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Main Authors: Chen, Ching-ju, Tobiason, Deborah M., Thomas, Christopher E., Shafer, William M., Seifert, H. Steven, Sparling, P. Frederick
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Molecular Biology of Pathogens
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC321488/
https://ncbi.nlm.nih.gov/pubmed/14729699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.3.730-739.2004
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