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The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability

The penC resistance gene was previously characterized in a FA19 penA mtrR penB gonococcal strain (PR100) as a spontaneous mutation that increased resistance to penicillin and tetracycline. We show here that antibiotic resistance mediated by penC is the result of a Glu-666 to Lys missense mutation in...

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Detalhes bibliográficos
Main Authors: Zhao, Shuqing, Tobiason, Deborah M., Hu, Mei, Seifert, H. Steven, Nicholas, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673695/
https://ncbi.nlm.nih.gov/pubmed/16101998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2005.04752.x
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