Sensitivity of Malignant Rhabdoid Tumor cell lines to PD 0332991 is inversely correlated with p16 expression

Malignant rhabdoid tumor (MRT) is a rare and highly aggressive neoplasm of young children. MRT is characterized by inactivation of integrase interactor 1 (INI1). Cyclin-dependent kinase 4 (CDK4), which acts downstream of INI1, is required for the proliferation of MRT cells. Here we investigated the...

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Autori principali: Katsumi, Yoshiki, Iehara, Tomoko, Miyachi, Mitsuru, Yagyu, Shigeki, Tsubai-Shimizu, Satoko, Kikuchi, Ken, Tamura, Shinichi, Kuwahara, Yasumichi, Tsuchiya, Kunihiko, Kuroda, Hiroshi, Sugimoto, Tohru, Houghton, Peter J., Hosoi, Hajime
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214763/
https://ncbi.nlm.nih.gov/pubmed/21871868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.08.047
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