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Establishment of fibrillin-deficient osteoprogenitor cell lines identifies molecular abnormalities associated with extracellular matrix perturbation of osteogenic differentiation

Fibrillin-1 and fibrillin-2 are structural components of the extracellular matrix which are also involved in modulating local TGFβ and BMP bioavailability. Loss of fibrillin-1 or fibrillin-2 is associated with perturbed osteoblast maturation principally as the result of unbalanced TGFβ and BMP signa...

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Autors principals: Smaldone, Silvia, Carta, Luca, Ramirez, Francesco
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214762/
https://ncbi.nlm.nih.gov/pubmed/21538048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-011-1167-9
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