Insufficiently Defined Genetic Background Confounds Phenotypes in Transgenic Studies As Exemplified by Malaria Infection in Tlr9 Knockout Mice

The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases . However, a gene functions in a particular genomic context. This implies the importance of a well-def...

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Bibliographische Detailangaben
Hauptverfasser: Geurts, Nathalie, Martens, Erik, Verhenne, Sebastien, Lays, Natacha, Thijs, Greet, Magez, Stefan, Cauwe, Bénédicte, Li, Sandra, Heremans, Hubertine, Opdenakker, Ghislain, Van den Steen, Philippe E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214040/
https://ncbi.nlm.nih.gov/pubmed/22096530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027131
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