Insufficiently Defined Genetic Background Confounds Phenotypes in Transgenic Studies As Exemplified by Malaria Infection in Tlr9 Knockout Mice

The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases . However, a gene functions in a particular genomic context. This implies the importance of a well-def...

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Detalhes bibliográficos
Main Authors: Geurts, Nathalie, Martens, Erik, Verhenne, Sebastien, Lays, Natacha, Thijs, Greet, Magez, Stefan, Cauwe, Bénédicte, Li, Sandra, Heremans, Hubertine, Opdenakker, Ghislain, Van den Steen, Philippe E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214040/
https://ncbi.nlm.nih.gov/pubmed/22096530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027131
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