RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells

Survivin (SVV) is a multifunctional protein that has been implicated in the development of neointimal hyperplasia. Nuclear SVV is essential for mitosis, whereas in mitochondria SVV has a cytoprotective function. Here, we investigated the effects of RNA interference (RNAi)-mediated SVV knockdown on c...

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Detalhes bibliográficos
Principais autores: Nabzdyk, Christoph S., Lancero, Hope, Nguyen, Khanh P., Salek, Sherveen, Conte, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213959/
https://ncbi.nlm.nih.gov/pubmed/21856925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00089.2011
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