Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes

Studies suggest that soluble epoxide hydrolase (sEH) inhibition reduces end-organ damage in cardiovascular diseases. We hypothesize that sEH gene (Ephx2) knockout (KO) improves endothelial function and reduces renal injury in streptozotocin-induced diabetes. After 6 wk of diabetes, afferent arteriol...

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Bibliografische gegevens
Hoofdauteurs: Elmarakby, Ahmed A., Faulkner, Jessica, Al-Shabrawey, Mohammed, Wang, Mong-Heng, Maddipati, Krishna Rao, Imig, John D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2011
Onderwerpen:
Translational Physiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213948/
https://ncbi.nlm.nih.gov/pubmed/21832210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00759.2010
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