Therapeutic Liabilities of in Vivo Viral Vector Tropism: Adeno-Associated Virus Vectors, NMDAR1 Antisense, and Focal Seizure Sensitivity

The N-methyl-d-aspartic acid (NMDA) receptor provides a potential target for gene therapy of focal seizure disorders. To test this approach, we cloned a 729-bp NMDA receptor (NMDAR1) cDNA fragment in the antisense orientation into adeno-associated virus (AAV) vectors, where expression was driven by...

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Detaylı Bibliyografya
Asıl Yazarlar: Haberman, Rebecca P., Criswell, Hugh E., Snowdy, Stephen, Ming, Zhen, Breese, George R., Samulski, R. Jude, McCown, Thomas J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2002
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213639/
https://ncbi.nlm.nih.gov/pubmed/12377191
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