Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans

ABSTRACT: Elevated oxidized low-density lipoproteins (LDL) are associated with vascular dysfunction in the cutaneous microvasculature, induced in part by upregulated arginase activity and increased globalized oxidant stress. Since tetrahydrobiopterin (BH(4)) is an essential cofactor for endothelial...

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Autores principales: Holowatz, Lacy A, Kenney, W Larry
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2011
Materias:
Integrative
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213424/
https://ncbi.nlm.nih.gov/pubmed/21807618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.212100
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