Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca(2+) content in rat ventricular myocytes

ABSTRACT: Changes of the activity of the sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) affect the amplitude of the systolic Ca(2+) transient and thence cardiac contractility. This is thought to be due to alterations of SR Ca(2+) content. Recent work on mice in which the expression of SERCA is de...

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Autors principals: Bode, E F, Briston, S J, Overend, C L, O'Neill, S C, Trafford, A W, Eisner, D A
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2011
Matèries:
Cardiovascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213419/
https://ncbi.nlm.nih.gov/pubmed/21825024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.211052
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