Rapid Mapping and Identification of Mutations in Caenorhabditis elegans by Restriction Site-Associated DNA Mapping and Genomic Interval Pull-Down Sequencing

Forward genetic screens provide a powerful approach for inferring gene function on the basis of the phenotypes associated with mutated genes. However, determining the causal mutation by traditional mapping and candidate gene sequencing is often the rate-limiting step, especially when analyzing many...

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Main Authors: O’Rourke, Sean M., Yochem, John, Connolly, Amy A., Price, Meredith H., Carter, Luke, Lowry, Joshua B., Turnbull, Douglas W., Kamps-Hughes, Nick, Stiffler, Nicholas, Miller, Michael R., Johnson, Eric A., Bowerman, Bruce
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2011
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Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213368/
https://ncbi.nlm.nih.gov/pubmed/21900274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.134031
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