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MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
The MYCN gene plays a critical role in determining the clinical behavior of neuroblastoma. Although it is known that genomic amplification occurs in high-risk subsets, it remains unclear how MYCN expression is regulated in the pathogenesis of neuroblastomas. Herein, we report that MYCN expression wa...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3213308/ https://ncbi.nlm.nih.gov/pubmed/21822304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.343 |
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