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Mutation of the Phospholipase Catalytic Domain of the Pseudomonas aeruginosa Cytotoxin ExoU Abolishes Colonization Promoting Activity and Reduces Corneal Disease Severity
We have previously shown that ExoU, a type III secreted cytotoxin of Pseudomonas aeruginosa, causes acute cytotoxicity towards corneal epithelial cells in vitro, and contributes to corneal disease pathology and ocular colonization in vivo. Subsequently, we reported that ExoU represses phagocyte infi...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3213055/ https://ncbi.nlm.nih.gov/pubmed/17905228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2007.08.015 |
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