Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain

BACKGROUND: Mechanisms driving cancer-induced bone pain are poorly understood. A central factor implicated to be a key player in the process of tumorigenesis, osteoclastogenesis and nociception is p38 MAPK. We determined the role of p38 MAPK in a mouse model of breast cancer induced bone pain in whi...

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Hlavní autoři: Sukhtankar, Devki, Okun, Alec, Chandramouli, Anupama, Nelson, Mark A, Vanderah, Todd W, Cress, Anne E, Porreca, Frank, King, Tamara
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212934/
https://ncbi.nlm.nih.gov/pubmed/22014040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-81
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