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Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer

Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced...

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Détails bibliographiques
Auteurs principaux: King, Tamara, Vardanyan, Anna, Majuta, Lisa, Melemedjian, Ohannes, Nagle, Ray, Cress, Anne E., Vanderah, Todd W., Lai, Josephine, Porreca, Frank
Format: Artigo
Langue:Inglês
Publié: 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704581/
https://ncbi.nlm.nih.gov/pubmed/17706870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2007.06.026
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