Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner

BACKGROUND: CD4+ T helper type 2 (T(H)2) cells, their cytokines IL-4, IL-5 and IL-13 and the transcription factor STAT6 are known to regulate various features of asthma including lung inflammation, mucus production and airway hyperreactivity and also drive alternative activation of macrophages (AAM)...

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Autores principales: Dasgupta, Preeta, Chapoval, Svetlana P, Smith, Elizabeth P, Keegan, Achsah D
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212823/
https://ncbi.nlm.nih.gov/pubmed/22014099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-12-60
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