Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production

Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the classic antigen-binding site. To assess the role of D(H) RF1-encoded tyrosine and glycine in regulating CDR-H3 content and potentially influencing B cell function...

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Main Authors: Ippolito, Gregory C., Schelonka, Robert L., Zemlin, Michael, Ivanov, Ivaylo I., Kobayashi, Ryoki, Zemlin, Cosima, Gartland, G. Larry, Nitschke, Lars, Pelkonen, Jukka, Fujihashi, Kohtaro, Rajewsky, Klaus, Schroeder, Harry W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212734/
https://ncbi.nlm.nih.gov/pubmed/16754718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052217
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