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Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the classic antigen-binding site. To assess the role of D(H) RF1-encoded tyrosine and glycine in regulating CDR-H3 content and potentially influencing B cell function...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Rockefeller University Press
2006
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3212734/ https://ncbi.nlm.nih.gov/pubmed/16754718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052217 |
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