BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals

Here we investigate the function of zebrafish Bcl-2 family proteins and demonstrate important conservation of function across zebrafish and mammalian systems. We have isolated a zebrafish ortholog of mammalian BIM and show that it is the most toxic of the zebrafish BH3-only genes examined, sharing t...

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Bibliografiske detaljer
Main Authors: Jette, CA, Flanagan, AM, Ryan, J, Pyati, UJ, Carbonneau, S, Stewart, RA, Langenau, DM, Look, AT, Letai, A
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212414/
https://ncbi.nlm.nih.gov/pubmed/18404156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.42
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