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Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells

AIMS: Substance P and neurokinin A (NKA) are sensory nerve neuropeptides encoded by the TAC1 gene. Substance P is a mast cell secretagogue and mast cells are known to play a role in adverse myocardial remodelling. Therefore, we wondered whether substance P and/or NKA modulates myocardial remodelling...

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Detalhes bibliográficos
Main Authors: Meléndez, Giselle C., Li, Jianping, Law, Brittany A., Janicki, Joseph S., Supowit, Scott C., Levick, Scott P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211974/
https://ncbi.nlm.nih.gov/pubmed/21908647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr244
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