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TNF-α inhibition attenuates adverse myocardial remodeling in a rat model of volume overload

Tumor necrosis factor (TNF)-α is a proinflammatory cytokine that has been implicated in the pathogenesis of heart failure. In contrast, we have recently shown that myocardial levels of TNF-α are acutely elevated in the aortocaval (AV) fistula model of heart failure. Based on these observations, we h...

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Detalhes bibliográficos
Main Authors: Jobe, Lynetta J., Meléndez, Giselle C., Levick, Scott P., Du, Yan, Brower, Gregory L., Janicki, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770768/
https://ncbi.nlm.nih.gov/pubmed/19666842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00442.2009
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