Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma

PURPOSE: Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG. PATIENTS AND MET...

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Hlavní autoři: Paugh, Barbara S., Broniscer, Alberto, Qu, Chunxu, Miller, Claudia P., Zhang, Junyuan, Tatevossian, Ruth G., Olson, James M., Geyer, J. Russell, Chi, Susan N., da Silva, Nasjla Saba, Onar-Thomas, Arzu, Baker, Justin N., Gajjar, Amar, Ellison, David W., Baker, Suzanne J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2011
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209696/
https://ncbi.nlm.nih.gov/pubmed/21931021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.35.5677
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