The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents

Eitemau Tebyg

• Structural Exploration of (3S,6S)-6-Benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants
  gan: Santra, Soumava, et al.
  Cyhoeddwyd: (2012)
• An improved asymmetric synthetic route to a novel triple uptake inhibitor antidepressant (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol (D-142)
  gan: Gopishetty, Bhaskar, et al.
  Cyhoeddwyd: (2011)
• Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Identification of compounds with triple uptake inhibitory activity as potential antidepressant agents
  gan: Gopishetty, Bhaskar, et al.
  Cyhoeddwyd: (2011)
• Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/ 7-{[2-(4-Aryl- piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol
  gan: Ghosh, Balaram, et al.
  Cyhoeddwyd: (2010)
• Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?
  gan: Sharma, Horrick, et al.
  Cyhoeddwyd: (2015)