Stress-Stimulated Mitogen-Activated Protein Kinases Control the Stability and Activity of the Cdt1 DNA Replication Licensing Factor

DNA replication is tightly coordinated both with cell cycle cues and with responses to extracellular signals to maintain genome stability. We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mito...

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Bibliographic Details
Main Authors: Chandrasekaran, Srikripa, Tan, Ting Xu, Hall, Jonathan R., Cook, Jeanette Gowen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209262/
https://ncbi.nlm.nih.gov/pubmed/21930785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06163-11
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