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TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73
Nearly half of human cancers harbor p53 mutations, which can promote cancerous growth, metastasis, and resistance to therapy. The gain of function of mutant p53 is partly mediated by its ability to form a complex with NF-Y or p63/p73. Here, we demonstrate that TopBP1 mediates these activities in can...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209258/ https://ncbi.nlm.nih.gov/pubmed/21930790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05574-11 |
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