PRION-1 scales analysis supports use of functional outcome measures in prion disease

OBJECTIVES: Human prion diseases are heterogeneous but invariably fatal neurodegenerative disorders with no known effective therapy. PRION-1, the largest clinical trial in prion disease to date, showed no effect of the potential therapeutic quinacrine on survival. Although there are several limitati...

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Autors principals: Mead, S., Ranopa, M., Gopalakrishnan, G.S., Thompson, A.G.B., Rudge, P., Wroe, S., Kennedy, A., Hudson, F., MacKay, A., Darbyshire, J.H., Collinge, J., Walker, A.S.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208955/
https://ncbi.nlm.nih.gov/pubmed/22013183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182364890
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