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Quantitative proteomic identification of the BRCA1 ubiquitination substrates

Mutation of the BRCA1 tumor suppressor gene predisposes women to hereditary breast and ovarian cancers. BRCA1 forms a heterodimer with BARD1. The BRCA1/BARD1 heterodimer has ubiquitin ligase activity, considered to play crucial roles in tumor suppression and DNA damage response. Nevertheless, releva...

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Bibliografiske detaljer
Main Authors: Song, Meihua, Hakala, Kevin, Weintraub, Susan T., Shiio, Yuzuru
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208807/
https://ncbi.nlm.nih.gov/pubmed/21950761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr200662b
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